Clinical Data Consultant

My responsibilities are

Postdoctoral Researcher

Microbiology Specialist

(Ongoing affiliation)

Microbiology Specialist

Physician. Primary Care Service

FEMS Congress Grant for Young Scientists

2214-A Scientific and Technological Research Council of Turkey

Visiting research student, January-October 2018, Mardinoglu Lab, KTH Royal Institute of Technology, Stockholm, Sweden   

KLIMUD Attendance Grant

3rd Best Research Award

Serotype Distribution and Antimicrobial Susceptibility of Streptococcus pneumoniae Causing  Invasive Pneumococcal Disease in Adults in Turkey, 2005-2011; 6th National Vaccine Symposium, 21-25 October 2015, Ankara, Turkey  

PhD in Medical Microbiology

Thesis title: Investigation of Burkholderia Species by Molecular Methods, Typing, Formation of Biofilm Between Species and Determination of Antibiotic Resistance Difference

Specialty in Medical Microbiology

Thesis title: The Role of Universal Primers for Rapid Detection of Bacterial Pathogens in Blood Samples of Patients with Fever

Doctor of Medicine

Combined Metabolic Activators Improve Cognitive Functions without Altering Motor Scores in Parkinson’s Disease

Under Review

Yulug B, Altay O,  Li X, Hanoglu L, Cankaya S, Lam S, Yang H, Coskun E, İdil E, Nogaylar R, Hacımuftuoglu A, Arif M, Shoaie S, Zhang C, Nielsen J, Turkez H, Borén J, Uhlén M, Mardinoglu A.

doi: https://doi.org/10.1101/2021.07.28.21261293 Co-first author

Combined metabolic activators improve cognitive functions in Alzheimer's disease patients: a randomised, double-blinded, placebo-controlled phase-II trial

Yulug B, Altay O, Li X, Hanoglu L, Cankaya S, Lam S, Velioglu HA, Yang H, Coskun E, Idil E, Nogaylar R, Ozsimsek A, Bayram C, Bolat I, Oner S, Tozlu OO, Arslan ME, Hacimuftuoglu A, Yildirim S, Arif M, Shoaie S, Zhang C, Nielsen J, Turkez H, Borén J, Uhlén M, Mardinoglu A.

doi: 10.1186/s40035-023-00336-2 Co-first author

Combined Metabolic Activators Accelerates Recovery in Mild-to-Moderate COVID-19

Altay, O., Arif, M., Li, X., Yang, H., Aydın, M., Alkurt, G., Kim, W., Akyol, D., Zhang, C., Dinler-Doganay, G., Turkez, H., Shoaie, S., Nielsen, J., Borén, J., Olmuscelik, O., Doganay, L., Uhlén, M., Mardinoglu,A.

https://doi.org/10.1002/advs.202101222. Co-first author

Multi-omics analysis reveals the impact of microbiota on host metabolism in hepatic steatosis

Zeybel M, Arif M, Li X,  Altay O, Shi M, Akyildiz M, Saglam B, Gonenli MG, Yigit B, Ulukan B, Ural D, Shoaie S, Turkez H , Nielsen J, Zhang C , Uhlén M, Borén J, Mardinoglu A.

2104373. https://doi.org/10.1002/advs.202104373

Revealing the Metabolic Alterations during Biofilm Development of Burkholderia cenocepacia Based on Genome-Scale Metabolic Modeling

Altay O, Zhang C, Turkez H, Nielsen J, Uhlén M, Mardinoglu A.

doi: 10.3390/metabo11040221. First author

Combined metabolic activators therapy ameliorates liver fat in nonalcoholic fatty liver disease patients

Zeybel M, Altay O, Arif M, Li X, Yang H, Fredolini C, Akyildiz M, Saglam B, Gonenli MG, Ural D, Kim W, Schwenk JM, Zhang C, Shoaie S, Nielsen J, Uhlén M, Borén J, Mardinoglu A.

doi: 10.15252/msb.202110459. PMID: 34694070. Co-first author

Systems biology based drug repositioning for development of cancer therapy

Turanli B, Altay O, Borén J, Turkez H, Nielsen J, Uhlén M, Arga KY, Mardinoglu A.

doi: 10.1016/j.semcancer.2019.09.020. PMID: 31568815. Co-first author

Next generation plasma proteome profiling of COVID-19 patients with mild to moderate symptoms

Zhong W, Altay O, Arif M, Edfors F, Doganay L, Mardinoglu A, Uhlen M, Fagerberg L.

74:103723. doi: 10.1016/j.ebiom.2021.103723

A single-cell type transcriptomics map of human tissues

Karlsson M, Zhang C, Méar L, Zhong W, Digre A, Katona B, Sjöstedt E, Butler L, Odeberg J, Dusart P, Edfors F, Oksvold P, von Feilitzen K, Zwahlen M, Arif M, Altay O, Li X, Ozcan M, Mardonoglu A, Fagerberg L, Mulder J, Luo Y, Ponten F, Uhlén M, Lindskog C.

Addressing the heterogeneity in liver diseases using biological networks

Lam S, Doran S, Yuksel HH, Altay O, Turkez H, Nielsen J, Boren J, Uhlén M, Mardinoglu A.

doi: 10.1093/bib/bbaa002

Revealing the Molecular Mechanisms of Alzheimer's Disease Based on Network Analysis

Bayraktar A, Lam S, Altay O, Li X, Yuan M, Zhang C, Arif M, Turkez H, Uhlén M, Shoaie S, Mardinoglu A.

doi: 10.3390/ijms222111556. PMID: 34768988; PMCID: PMC8584243

Systems Biology Approaches to Decipher the Underlying Molecular Mechanisms of Glioblastoma Multiforme

Kaynar A, Altay O, Li X, Zhang C, Turkez H, Uhlén M, Shoaie S, Mardinoglu A.

doi: 10.3390/ijms222413213. PMID: 34948010; PMCID: PMC8706582.

Improvement of the performance of anticancer peptides using a drug repositioning pipeline

Mohammadi E, Tahmoorespur M, Benfeitas R, Altay O, Javadmanesh A, Lam S, Mardinoglu A, Sekhavati MH.

doi: 10.1002/biot.202100417. Epub ahead of print. PMID: 34657375.

Serotype distribution of Streptococcus pneumonia in children with invasive disease in Turkey: 2015-2018

Ceyhan M, Aykac K, Gurler N, Ozsurekci Y, Oksuz L, Altay Akisoglu O, Oz FN, Emiroglu M, Turkdagi H, Yaman A, Soyletir G, Ozturk C, Akpolat N, Ozakin C, Aydın F, Aydemir S, Kiremitci A, Gültekin M, Camcıoglu Y, Zer Y, Guducuoğlu H, Gulay Z, Birinci A, Arabaci C, Karbuz A, Devrim I, Sorguc Y, Baysan BO, Karadag Oncel E, Yilmaz N, Altintop YA.

doi: 10.1080/21645515.2020.1747931. Epub 2020 Jun 12.

Current Status of COVID-19 Therapies and Drug Repositioning Applications

Altay O, Mohammadi E, Lam S, Turkez H, Boren J, Nielsen J, Uhlen M, Mardinoglu A.

doi: 10.1016/j.isci.2020.101303. Epub 2020 Jun 20. Co-first author

Improvement in the Current Therapies for Hepatocellular Carcinoma Using a Systems Medicine Approach

Ozcan M, Altay O, Lam S, Turkez H, Aksoy Y, Nielsen J, Uhlén M, Boren J, Mardinoglu A.

doi: 10.1002/adbi.202000030.

Identification of Viridans Group Streptococci in Clinical Isolates: Comparison of Two Matrix-Assisted Laser Desorption-Ionization Time of Flight Mass Spectrometry Systems and a Conventional Phenotypic Method

Hascelik G, Altay O, Karacan N, Ozdal Salar M, Mustak HK.

Multicenter Hospital-Based Prospective Surveillance Study of Bacterial Agents Causing Meningitis and Seroprevalence of Different Serogroups of Neisseria meningitidis, Haemophilus influenzae Type b, and Streptococcus pneumoniae during 2015 to 2018 in Turkey

Ceyhan M, Ozsurekci Y, Tanır Basaranoglu S, Gurler N, Sali E, Keser Emiroglu M, Oz FN, Belet N, Duman M, Ulusoy E, Kurugol Z, Tezer H, Ozkaya Parlakay A, Dinleyici EC, Celik U, Celebi S, Oner AF, Solmaz MA, Karbuz A, Hatipoglu N, Devrim I, Caglar I, Bozdemir SE, Kocabas E, Gundeslioglu OO, Sutcu M, Metin Akcan O, Kuyucu N, Aktar F, Kara SS, Altay Akisoglu HO, Tuygun N, Tamburaci Uslu ZD, Karadag Oncel E, Bayhan C, Cengiz AB.

doi: 10.1128/mSphere.00060-20.

Systems biology perspective for studying the gut microbiota in human physiology and liver diseases

Altay O, Nielsen J, Uhlén M, Boren J, Mardinoglu A.

doi: 10.1016/j.ebiom.2019.09.057. First author

Multilocus sequence analysis, biofilm production, antibiotic susceptibility and synergy tests of Burkholderia species in patients with and without cystic fibrosis

Akisoglu O, Engin D, Sarıçam S, Mustak HK, Şener B, Hasçelik G.

doi: 10.5578/mb.67730. First author

Neisseria meningitidis Serogroup X ST-5799 (ST-22 complex) in Turkey: A unique pediatric case

Tanır G, Ozsurekci Y, Lucidarme J, Yaşar Durmuş S, Lekshmi A, Akisoglu O, Aycan AE, Borrow R, Ceyhan M.

Hum Vaccin Immunother. 2018 Jan 2;14(1):209-212

Genome-scale metabolic modeling revealed micro-environmental effects on pathogenic bacteria of cystic fibrosis lung

Akisoglu O, Rosario D, Benfeitas R, Bidkhori G, Zhang Z, Hascelik G, Mardinoglu A. 

Prevalence of nasal carriage of methicillin-resistant Staphylococcus aureus in children with diabetes mellitus: Trends between 2005 and 2013

Karadag-Oncel E, Gonc N, Altay O, Cengiz AB, Ozon A, Pinar A, Ceyhan M, Alikasifoglu A, Akyon Y, Kandemir N, Ozsurekci Y, Kara A.

2015 Sep 1;43(9):1015-7.  

Rapid Detection of Bacteremia in Febrile Patients Using the Universal Primers

Altay O, Pinar A, Ortaç E, Topeli A, Ozkuyumcu

The Human Power in Microbiology Laboratories: Perspective of Research Assistants

Altay O

Society for Clinical Microbiologist of Turkey (KLIMUD)

Ankara Microbiology Society

Society for Clinical Microbiologist of Turkey (KLIMUD)

European Society of Clinical Microbiology and Infectious Diseases (ESCMID)

American Society for Microbiology (ASM)

Co-supervision master theses student

Lectures and lead a 6-day workshop in the M.Sc. program

Lectures of Systems Biology of Human Metabolism and Gut Microbiome course

Supervision of Microbiology laboratory

Microbiology laboratory hours to the medical faculty students from 1st to 3rd grades (≈240 hours)

Co-supervision

Co-supervision a visiting PhD student and 6 Erasmus exchange programme students , 5 visiting bachelor students

Educational and training programs for laboratory staff

Visiting research student

Visiting research student

Student exchange program